News & Views | Published:

Are we any closer to genetic testing for common malignancies?

Nature Medicine volume 2, pages 156158 (1996) | Download Citation

Subjects

Simple cost-effective strategies for genetic testing of HNPCC are proposed (pages 169–174), but many questions must be answered before testing for inherited forms of common cancers becomes a widespread reality.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families. Am. J. Hum. Genet. 57, 1284–1297 (1995).

  2. 2.

    et al. Mutations of a mutS homolog in hereditary non-polyposis colorectal cancer. Cell 75, 1215–1225 (1995).

  3. 3.

    et al. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nature Med. 2, 169–174 (1996).

  4. 4.

    et al. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene 10, 33–37 (1996).

  5. 5.

    et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66–71 (1996).

  6. 6.

    et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789–763 (1995).

  7. 7.

    et al. Rapid detection of BRCA1 mutation by the protien truncation test Nature Genet. 10, 208–212 (1995).

  8. 8.

    et al. Detection of BRCA1 mutations by the protein truncation test. Hum. Mol. Genet. 4, 1989–1991 (1995).

  9. 9.

    et al. A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families. Am. J. Hum. Genet. 58, 42–51 (1996).

  10. 10.

    et al. Aberrant subcellular localization of BRCA1 in breast cancer. Science 270 789–791 (1995).

  11. 11.

    et al. Genetic Counseling for families with inherited susceptibility to breast and ovarian cancer. JAMA 269, 1970–1974 (1993).

  12. 12.

    et al. Informed consent and BRCA1 testing. Nature Genet. 11, 364 (1995).

Download references

Author information

Affiliations

  1. Department of Cancer Biology, The Cleveland Clinic Research Institute, 9500 Euclid Avenue Cleveland, Ohio 44195, USA

    • Sarah J. Plummer
    •  & Graham Casey

Authors

  1. Search for Sarah J. Plummer in:

  2. Search for Graham Casey in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm0296-156

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing