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Are we any closer to genetic testing for common malignancies?

Simple cost-effective strategies for genetic testing of HNPCC are proposed (pages 169–174), but many questions must be answered before testing for inherited forms of common cancers becomes a widespread reality.

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References

  1. Friedman, L.S. et al. Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families. Am. J. Hum. Genet. 57, 1284–1297 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Leach, F.S. et al. Mutations of a mutS homolog in hereditary non-polyposis colorectal cancer. Cell 75, 1215–1225 (1995).

    Article  Google Scholar 

  3. Liu, B. et al. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nature Med. 2, 169–174 (1996).

    Article  CAS  PubMed  Google Scholar 

  4. Eshleman, J.R. et al. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene 10, 33–37 (1996).

    Google Scholar 

  5. Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66–71 (1996).

    Article  Google Scholar 

  6. Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789–763 (1995).

    Article  CAS  PubMed  Google Scholar 

  7. Hogervorst, F.B.L. et al. Rapid detection of BRCA1 mutation by the protien truncation test Nature Genet. 10, 208–212 (1995).

    Article  CAS  PubMed  Google Scholar 

  8. Plummer, S.J. et al. Detection of BRCA1 mutations by the protein truncation test. Hum. Mol. Genet. 4, 1989–1991 (1995).

    Article  CAS  PubMed  Google Scholar 

  9. Serova, O. et al. A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families. Am. J. Hum. Genet. 58, 42–51 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Chen, Y. et al. Aberrant subcellular localization of BRCA1 in breast cancer. Science 270 789–791 (1995).

    Article  CAS  PubMed  Google Scholar 

  11. Biesecker, B.B. et al. Genetic Counseling for families with inherited susceptibility to breast and ovarian cancer. JAMA 269, 1970–1974 (1993).

    Article  CAS  PubMed  Google Scholar 

  12. Geller, G. et al. Informed consent and BRCA1 testing. Nature Genet. 11, 364 (1995).

    Article  CAS  PubMed  Google Scholar 

Download references

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Plummer, S., Casey, G. Are we any closer to genetic testing for common malignancies?. Nat Med 2, 156–158 (1996). https://doi.org/10.1038/nm0296-156

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