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…and surreal antisense?

Nature Medicinevolume 2pages131132 (1996) | Download Citation



  1. 1

    Stein, C.A. Does antisense exist?. Nature Med. 1, 1119–1121 (1995).

  2. 2

    Abe, J. et al. Suppression of neointimal smooth muscle cell accumulation in vivoby antisense cdc2 and cdk2 oligonucleotides in rat carotid artery. Biochem. Biophys. Res. Comrnun. 198, 16–24 (1994).

  3. 3

    Edelman, E.R., Simons, M., Sirois, M.G. & Rosenberg, R.D. C-myc in vasculoproiiferative disease. Circ. Res. 76, 176–182 (1995).

  4. 4

    Simons, M., Edelman, E.R. & Rosenberg, R.D. Antisense PCNA oligonucleotides inhibit intimal hyperplasia in a rat carotid injury model. J. Clin. Invest. 93, 2351–2356 (1994).

  5. 5

    Morishita, R. et al. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc. Natl. Acad. Sci. USA 90, 8474–8478 (1993).

  6. 6

    Sirois, M., Simons, M., Edelman, E.R., Kuter, D.J. & Rosenberg, R.D. Platelet release of platelet-derived growth factor is required for intimal hyperplasia in rat vascular injury model. Circulation 90, 1–511 (1994).

  7. 7

    Lindner, V. & Reidy, M.A. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc. Natl. Acad. Sci. USA 89, 3739–3743 (1991).

  8. 8

    Husain, M. et al. Dominant negative c-myb constructs lower intracellular calcium levels and slow cell cycle progression in vascular smooth muscle cells. Circulation 92, 1–299 (1995).

  9. 9

    Burgess, T. et al. The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc. Natl. Acad.Sci. USA 92, 4051–4055 (1995).

  10. 11

    Villa, A. et al. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ. Res. 76, 505–513 (1995).

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  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    • Michael Simons
    •  & Robert D. Rosenberg
  2. Department of Medicine, Beth Israel Hospital, Boston, Massachusetts, 02215, USA

    • Michael Simons
    •  & Robert D. Rosenberg
  3. Department of Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 02215, USA

    • Elazer R. Edelman
  4. Department of Health, Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    • Elazer R. Edelman


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