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Exploring the universe of molecules for new drugs

Nature Medicine volume 1, pages 177–178 (1995)Cite this article

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References

  1. Thaisrivongs, S., et al. Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyronses as non-peptidic inhibitors. J. med. Chem. 37, 3200–3204 (1994).

    Article  CAS  Google Scholar 

  2. Bohacek, R.S., & McMartin, C., Multiple highly diverse structures complementary to enzyme binding sites: Results of extensive application of a de novo design method incorporating combinatorial growth. J. Am. chem. Soc. 116, 5560–5571 (1994).

    Article  CAS  Google Scholar 

  3. Roderick, S.L., Fournie-Zaluski, B.P., Roques, B.P., & Matthews, B.W., Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin. Biochemistry 28, 1493–1497 (1989).

    Article  CAS  Google Scholar 

  4. Bohacek, R.S., & McMartin, C., Definition and display of steric, hydrophobic and hydrogen bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: Validation of a high-resolution graphical tool for drug design. J. med. Chem. 35, 1671–1684 (1992).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Department, Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, New Jersey, 17901, USA

    Regine S. Bohacek & Colin McMartin

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  1. Regine S. Bohacek
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  2. Colin McMartin
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Bohacek, R., McMartin, C. Exploring the universe of molecules for new drugs. Nat Med 1, 177–178 (1995). https://doi.org/10.1038/nm0295-177

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