Apoptosis in HIV infection

It is reported that DNA fragmentation (indicating apoptosis) is rarely observed in HIV-1 or SIV-producing infected cells, and HIV-1 or SIV RNA is rarely (0-1%) observed in apoptotic cells. What is the role of apoptosis in the pathogenicity of HIV infection? (pages 129–134)

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Terai, C., Kornbluth, R.S., Pauza, C.D., Richman, D.D. & Carson, D.A. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV–1. J. clin. Invest. 87, 1710–1715 (1991).

  2. 2

    Laurent-Crawford, A.G., Krust, B. & Muller, S. The cytopathic effect of HIV is associated with apoptosis. Virology 185, 829–839 (1991).

  3. 3

    Ameisen, J.C. & Capron, A. Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis. Immunol. Today 12, 102–105 (1991).

  4. 4

    Gougeon, M.L. et al. Mise en evidence d'un processus d'engagment vers la mort cellulaire par apoptose dans les lymphocytes de patients infectes par le VIH. C. R. Acad. Sci. Paris Ser II Sci. Vie 312, 529–537 (1991).

  5. 5

    Meyaard, L. et al. Programmed death of T cells in HIV-1 infection. Science 257, 217–219 (1992).

  6. 6

    Banda, N.K. et al. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 176, 1099–1106 (1992).

  7. 7

    Finkel, T.H. et al. Apoptosis occurs predominant-lyon bystander cells and not in productively infected cells of HIV-and SIV-infected Lymph nodes. Nature Med. 1, 129–134 (1995)

  8. 8

    Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355–359 (1993).

  9. 9

    Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359–362 (1993).

  10. 10

    Meyaard, L. et al. J. clin. Invest. 93, 982 (1994).

  11. 11

    Pantaleo, G. et al. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol. Rev. 140, 105–130 (1994).

  12. 12

    Cohen, J.J. et al. Ann. Rev. Immunol. (1992).

  13. 13

    Lenardo, M.J. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353, 858–861 (1991).

  14. 14

    Wesselborg, S., Janssen, O. & Kabelitz, D. Induction of activation–driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 150, 4338–4345 (1993).

  15. 15

    Ascher, M.S. & Sheppard, H.W. AIDS as immune system activation. II. The Panergic Imnesia Hypothesis. J. AIDS 3, 177–191 (1990).

  16. 16

    Pantaleo, G. & Fauci, A.S. Tracking HIV during disease progression. Curr. Opin. Immunol. 6, 600–604 (1994).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading