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Linking the inflammasome to obesity-related disease

Nature Medicine volume 17, pages 164165 (2011) | Download Citation

Chronic inflammation is associated with obesity, but the pathways that mediate this phenomenon are not fully characterized. The nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (Nlrp3) inflammasome functions as a sensor to detect danger signals and induce downstream inflammatory signaling that contributes to obesity-associated conditions such as insulin resistance (pages 179–188).

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Affiliations

  1. Tiffany Horng and Gökhan S. Hotamisligil are in the Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.

    • Tiffany Horng
    •  & Gökhan S Hotamisligil

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The authors declare no competing financial interests.

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Correspondence to Tiffany Horng or Gökhan S Hotamisligil.

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DOI

https://doi.org/10.1038/nm0211-164

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