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Breaking into bone biology: target practice

Osteoporosis researchers do not suffer from a lack of potential drug targets—so one challenge is to decide which ones to focus on. Yongwon Choi, Matthew C. Walsh and Joseph R. Arron now examine several molecules involved in bone biology and assess their prospects. In a second commentary, Cliff Rosen analyzes findings that serotonin, derived from the gut, regulates bone formation. The findings not only could lead to new drug targets, they also could help explain clinical data that serotonin reuptake inhibitors—widely prescribed as antidepressants—weaken bones.

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Figure 1: Targeting the osteoclast.

Katie Vicari


  1. Raisz, L.G. et al. in Williams Textbook of Endocrinology Vol. 10 (eds. Davies, T.F., Larson, P.R. & Kronenberg, H.M.) 1373 (W.B. Saunders, Philadelphia, 2002).

    Google Scholar 

  2. United States Public Health Service. Bone Health and Osteoporosis: A Report Of The Surgeon General. (US Department of Health and Human Services, Washington, DC, 2004).

  3. Russell, R.G. et al. Ann. NY Acad. Sci. 1117, 209–257 (2007).

    Article  CAS  Google Scholar 

  4. Brown, J.P. et al. J. Bone Miner. Res. 24, 153–161 (2009).

    Article  CAS  Google Scholar 

  5. Shinohara, M. et al. Cell 132, 794–806 (2008).

    Article  CAS  Google Scholar 

  6. Asagiri, M. et al. Science 319, 624–627 (2008).

    Article  CAS  Google Scholar 

  7. Iwasaki, R. et al. Biochem. Biophys. Res. Commun. 377, 899–904 (2008).

    Article  CAS  Google Scholar 

  8. Walsh, M.C. et al. Annu. Rev. Immunol. 24, 33–63 (2006).

    Article  CAS  Google Scholar 

  9. Takayanagi, H. Nat. Rev. Immunol. 7, 292–304 (2007).

    Article  CAS  Google Scholar 

  10. Martin, T.J. & Sims, N.A. Trends Mol. Med. 11, 76–81 (2005).

    Article  CAS  Google Scholar 

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J.R.A. is a full-time employee of Genentech, Inc.

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Choi, Y., Walsh, M. & Arron, J. Breaking into bone biology: target practice. Nat Med 15, 144–145 (2009).

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