A deader vaccine?

Generating live attenuated vaccines through repeated passages in cells and animals has been standard procedure for more than a century. A more targeted approach may lie on the horizon (pages 154–161).

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Figure 1: Polio stays put.

Katie Ris-Vicari


  1. 1

    Minor, P.D. Nat. Rev. Microbiol. 2, 473–482 (2004).

    CAS  Article  Google Scholar 

  2. 2

    Vignuzzi, M., Wendt, E. & Andino, R. Nat. Med. 14, 154–161 (2008).

    CAS  Article  Google Scholar 

  3. 3

    Drake, J.W. Ann. NY Acad. Sci. 870, 100–107 (1999).

    CAS  Article  Google Scholar 

  4. 4

    Vignuzzi, M., Stone, J.K., Arnold, J.J., Cameron, C.E. & Andino, R. Nature 439, 344–348 (2006).

    CAS  Article  Google Scholar 

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Minor, P. A deader vaccine?. Nat Med 14, 120–121 (2008). https://doi.org/10.1038/nm0208-120

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