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Staying in SHIP shape

The phosphatase SHIP2 has been the focus of drug development efforts for diabetes. This distinction is based in part on work suggesting that the molecule is central to the regulation of glucose levels in tissues and blood. An analysis of a SHIP2 knockout mouse changes this viewpoint and provides new directions for therapeutic intervention (pages 199–205).

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Figure 1: Negative regulation of PI3K signaling.

Kimberly Caesar


  1. Sleeman, M.W., Wortley, K.E., Lai, K.-M., Gowen, L.C. & Kinter, J. Nat. Med. 11, 199–205 (2005).

    Article  CAS  Google Scholar 

  2. Saltiel, A.R. & Kahn, C.R. Nature 414, 799–806 (2001).

    Article  CAS  Google Scholar 

  3. Fruman, D.A., Meyers, R.E. & Cantley, L.C. Annu. Rev. Biochem. 67, 481–507 (1998).

    Article  CAS  Google Scholar 

  4. Maehama, T. & Dixon, J.E. Trends Cell Biol. 9, 125–128 (1999).

    Article  CAS  Google Scholar 

  5. Pesesse, X., Deleu, S., De Smedt, F., Drayer, L. & Erneux, C. Biochem. Biophys. Res. Commun. 239, 697–700 (1997).

    Article  CAS  Google Scholar 

  6. Habib, T., Hejna, J.A., Moses, R.E. & Decker, S.J. J. Biol. Chem. 273, 18605–18609 (1998).

    Article  CAS  Google Scholar 

  7. Clement, S. et al. Nature 409, 92–97 (2001).

    Article  CAS  Google Scholar 

  8. Clement S. et al. Nature 431, 878 (2004).

    Article  CAS  Google Scholar 

  9. Nandi, A., Kitamura, Y., Kahn, C.R. & Accili, D. Physiol. Rev. 84, 623–647 (2004).

    Article  CAS  Google Scholar 

  10. Um, S.H. et al. Nature 431, 200–205 (2004).

    Article  CAS  Google Scholar 

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Decker, S., Saltiel, A. Staying in SHIP shape. Nat Med 11, 123–124 (2005).

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