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Cholesterol, racial variation and targeted medicines

One in 50 African-Americans have nonsense mutations in a gene that regulates cholesterol levels, PCSK9, accounting for a substantial lowering of blood LDL-cholesterol.

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Figure 1: Schematic of PCSK9.


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Topol, E. Cholesterol, racial variation and targeted medicines. Nat Med 11, 122–123 (2005).

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