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ACE sets up fertilization

The ACE enzyme, a target of blood pressure medications, now gains a new function in mice. The enzyme cleaves proteins linked to the cell membrane by GPI linkages, an activity required for fertilization (pages 160–166).

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Figure 1: ACE in egg fertilization.

Ann Thomson


  1. Kondoh, G. et al. Nat. Med. 11, 160–166 (2005).

    Article  CAS  Google Scholar 

  2. Corvol, P. et al. in Handbook of Proteolytic Enzymes (eds Barret A.J. et al.) 332–349 (Elsevier Academic Press, New York, 2004).

    Book  Google Scholar 

  3. Howard, T.E. et al. Mol. Cell Biol. 13, 1–27 (1990).

    Google Scholar 

  4. Krege, J.H. et al. Nature 375, 146–148 (1995).

    Article  CAS  Google Scholar 

  5. Esther, C.R. et al. Lab. Invest. 74, 953–965 (1996).

    CAS  PubMed  Google Scholar 

  6. Hagaman, J.R. et al. Proc. Natl. Acad. Sci. USA 95, 2552–2557 (1998).

    Article  CAS  Google Scholar 

  7. Wei, L. et al. J. Biol. Chem. 266, 9002–9008 (1992).

    Google Scholar 

  8. Natesh, R. et al. Nature 421, 551–554 (2003).

    Article  CAS  Google Scholar 

  9. Cornell, M.J. et al. J. Biol. Chem. 270, 13613–13619 (1995).

    Article  CAS  Google Scholar 

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Corvol, P. ACE sets up fertilization. Nat Med 11, 118–119 (2005).

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