As the major activator of HIV transcription, Tat drives viral gene expression. Now, it seems that in dendritic cells Tat also regulates the expression of chemokines that promote lymphocyte and monocyte migration. By recruiting susceptible host cells to infected dendritic cells, Tat may facilitate HIV dissemination (pages 191–197).
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Courtesy of Beth Mellor
Karla J. Daniels, David R. Soll, University of Iowa
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Stevenson, M. Tat's seductive side. Nat Med 9, 163–164 (2003). https://doi.org/10.1038/nm0203-163
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DOI: https://doi.org/10.1038/nm0203-163
