Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Murder mysteries in type 1 diabetes

Nervous system cells surrounding insulin-producing cells in the pancreas are destroyed early in the development type 1 diabetes, reveals a new study. The findings broaden our ideas of the disease process and may lead to new prediagnostic markers and therapies (pages 198–205).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Models of the initiation and progression of type 1 diabetes.

References

  1. Tisch, R. & McDevitt, H. Insulin-dependent diabetes mellitus. Cell 85, 291–297 (1996).

    Article  CAS  Google Scholar 

  2. Salomon, B. et al. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2- deficient NOD mice. J. Exp. Med. 194, 677–684 (2001).

    Article  CAS  Google Scholar 

  3. Winer, S. et al. Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis. J. Immunol. 166, 2831–2841 (2001).

    Article  CAS  Google Scholar 

  4. Winer, S. et al. Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive. Nat. Med. 9, 198–205 (2003).

    Article  CAS  Google Scholar 

  5. Teitelman, G., Guz, Y., Ivkovic, S. & Ehrlich, M. Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells. J. Neurobiol. 34, 304–318 (1998).

    Article  CAS  Google Scholar 

  6. Sunami, E. et al. Morphological characteristics of Schwann cells in the islets of Langerhans of the murine pancreas. Arch. Histol. Cytol. 64, 191–201 (2001).

    Article  CAS  Google Scholar 

  7. Sreenan, S. et al. Increased β-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48, 989–996 (1999).

    Article  CAS  Google Scholar 

  8. Mathis, D., Vence, L. & Benoist, C. β-Cell death during progression to diabetes. Nature 414, 792–798 (2001).

    Article  CAS  Google Scholar 

  9. Tian, J., Gregori, S., Adorini, L. & Kaufman, D.L. The frequency of high avidity T cells determines the hierarchy of determinant spreading. J. Immunol. 166, 7144–7150 (2001).

    Article  CAS  Google Scholar 

  10. Haskins, K. & Wegmann, D. Diabetogenic T-cell clones. Diabetes 45, 1299–1305 (1996).

    Article  CAS  Google Scholar 

  11. von Herrath, M.G. Regulation of virally induced autoimmunity and immunopathology: contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus. Curr. Top. Microbiol. Immunol. 263, 145–175 (2002).

    CAS  PubMed  Google Scholar 

  12. Larger, E., Becourt, C., Bach, J.F. & Boitard, C. Pancreatic islet β-cells drive T cell-immune responses in the nonobese diabetic mouse model. J. Exp. Med. 181, 1635–1642 (1995).

    Article  CAS  Google Scholar 

  13. Kaufman, D.L. et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69–72 (1993).

    Article  CAS  Google Scholar 

  14. French, M.B. et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 46, 34–39 (1997).

    Article  CAS  Google Scholar 

  15. Saravia-Fernandez, F. et al. Localization of γ-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse. Endocrinology 137, 3497–3506 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaufman, D. Murder mysteries in type 1 diabetes. Nat Med 9, 161–162 (2003). https://doi.org/10.1038/nm0203-161

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0203-161

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing