Migraine sufferers experience pounding headaches, which sometimes are preceded by a visual aura. Now Bolay et al. show that cortical-spreading depression, the cause of the aura, activates trigeminal afferents, which act to cause inflammation of the pain-sensitive meninges, generating the headache. (pages 136–142)
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Mechanisms of migraine as a chronic evolutive condition
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Iadecola, C. From CSD to headache: A long and winding road. Nat Med 8, 110–112 (2002). https://doi.org/10.1038/nm0202-110
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DOI: https://doi.org/10.1038/nm0202-110
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