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Myelination of the canine central nervous system by glial cell transplantation: A model for repair of human myelin disease

Nature Medicine volume 3, pages 54–59 (1997)Cite this article

Abstract

There is a lack of effective means of promoting remyelination of the central nervous system (CNS) in humans with chronic demyelinating disease. We have investigated the ability of transplanted glia to myelinate areas of the CNS equivalent to focal demyelinated lesions in multiple sclerosis (MS). In these studies we show that transplantation of oligodendrocytes or their progenitors into the CNS of a neonatal or adult canine myelin mutant results in repair of large areas similar in size to many MS plaques. Progenitor or pre-progenitor cells of the oligodendrocyte lineage have the greatest capacity for myelination following grafting, although cells of neonatal origin may also be used. Such an approach may therefore have therapeutic value in the repair of focal lesions in human myelin disease.

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Authors and Affiliations

  1. Department of Pediatrics, Emory University, 2040 Ridgewood Drive, NE, Atlanta, Georgia, 30322, USA

    D.R. Archer

  2. College of Veterinary Medicine, Colorado State University, 300 West Drake Road, Fort Collins, Colorado, 80523, USA

    P.A. Cuddon

  3. Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive West, Madison, Wisconsin, 53706, USA

    D. Lipsitz & I.D. Duncan

Authors
  1. D.R. Archer
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  2. P.A. Cuddon
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  3. D. Lipsitz
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  4. I.D. Duncan
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Archer, D., Cuddon, P., Lipsitz, D. et al. Myelination of the canine central nervous system by glial cell transplantation: A model for repair of human myelin disease. Nat Med 3, 54–59 (1997). https://doi.org/10.1038/nm0197-54

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