Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Janus faces of NF-κB: Neurodestruction versus neuroprotection

Aspirin may prevent neuronal cell death by inhibiting NF-κB, but what of NF-κB'S reported neuroprotective role?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lipton, S.A. & Rosenberg, P.A. Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613–622 (1994).

    Article  CAS  Google Scholar 

  2. Grilli, M., Pizzi, M., Memo, M. & Spano, P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science 274, 1383–1385 (1996).

    Article  CAS  Google Scholar 

  3. Kretz-Remy, C., Mehlen, P., Miralut, M.E. & Arrigo, A.P. Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-κB activation by glutathione peroxidase overexpression. J. Cell Biol. 133, 1083–1093 (1996).

    Article  CAS  Google Scholar 

  4. Ankarcrona, M. et al. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961–973 (1995).

    Article  CAS  Google Scholar 

  5. Lin, K.-I. et al. Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappaB. J. Cell Biol. 131, 1149–1161 (1995).

    Article  CAS  Google Scholar 

  6. Beg, A.A. & Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced Cell death. Science 274, 782–784 (1996).

    Article  CAS  Google Scholar 

  7. Wang, C.-Y., Mayo, M.W. & Baldwin, A.S. Jr., TNF-and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB. Science 274, 784–787 (1996).

    Article  CAS  Google Scholar 

  8. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R. & Verma, I.M. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787–789 (1996).

    Article  CAS  Google Scholar 

  9. Goodman, Y. & Mattson, M.P. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid β-peptide toxicity. J. Neurochem. 66, 869–872 (1996).

    Article  CAS  Google Scholar 

  10. Bauerle, P.A. & Baltimore, D., NF-κB: Ten years after. Cell 87, 13–n20 (1996).

    Article  Google Scholar 

  11. Obeid, L.M., Linardic, C.M., Karolak, L.A., & Hannun, Y.A., Programmed Cell death induced by ceramide. Science 259, 1769–1771 (1993).

    Article  CAS  Google Scholar 

  12. Verheij, M. et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380, 75–79 (1996).

    Article  CAS  Google Scholar 

  13. Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. & Greenberg, M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326–1331 (1995).

    Article  CAS  Google Scholar 

  14. Frade, J.M., Rodriguez-Tébar, A. & Barde, Y.-A. Induction of Cell death by endogenous nerve growth factor through its p75 receptor. Nature 383, 166–168 (1996).

    Article  CAS  Google Scholar 

  15. Schutze, S., Wiegman, K., Machleidt, T. & Krönke, M. TNF-induced activation of NF-kappa B. Immunobiology 193, 193–203 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lipton, S. Janus faces of NF-κB: Neurodestruction versus neuroprotection. Nat Med 3, 20–22 (1997). https://doi.org/10.1038/nm0197-20

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0197-20

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing