Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Live-attenuated HIV vaccines: How safe is safe enough?

A live-attenuated SIV vaccine inducing protection in healthy adult monkeys appears both safe and effective but may be lethal when given in high doses to newborns (pages 32–36).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Warren, J.T. & Levinson, M.A. Fourth annual survey of worldwide HIV, SIV, and SHIV challenge studies in vaccinated nonhuman primates. J. Med. Primatol. 24, 150–168 (1995).

    Article  CAS  PubMed  Google Scholar 

  2. Daniel, M.D., Kirchhoff, F., Czajak, S.C., Sehgal, P.K. & Desrosiers, R.C. Protective effects of a live-attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938–1941 (1992).

    Article  CAS  PubMed  Google Scholar 

  3. Wyand, M.S., Manson, K.H., Garcia-Moll, M., Montefiori, D. & Desrosiers, R.C. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J. Virol. 70, 3724 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Clements, J.E. et al. Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. J. Virol. 69, 2737–2744 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Lohman, B.L. et al. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J. Virol. 68, 7021–7029 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Baba, T.W. et al. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820–1825 (1995).

    Article  CAS  PubMed  Google Scholar 

  7. Gibbs, J.S., Regier, D.A. & Desrosiers, R.C. Construction and in vitro properties of SIVmac mutants with deletions in the “nonessential” genes. AIDS Res. Hum. Retroviruses 10, 607–616 (1994).

    Article  CAS  PubMed  Google Scholar 

  8. Wyand, M., Manson, K.H., Lackner, A.A. & Desrosiers, R.C. Resistance of neonatal monkeys to live-attenuated vaccine strains of simian immunodeficiency virus. Nature Med. 3, 32–36 (1997).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Murphey-Corb, M. Live-attenuated HIV vaccines: How safe is safe enough?. Nat Med 3, 17–18 (1997). https://doi.org/10.1038/nm0197-17

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0197-17

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing