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Anorexia nervosa, self–starvation and the reward of stress

Reduced intake of food and enhanced physical activity, the main behavioral manifestations of self-starvation and anorexia nervosa, activate brain substrates associated with reward.

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References

  1. Eckert, E.D. et al. Ten-year follow-up of anorexia nervosa: Clinical course and outcome. Psychol. Med. 25, 143–156 (1995).

    Article  CAS  Google Scholar 

  2. Lee, S., Ho, T.P. & Hsu, L.K.G. Fat phobic and non-fat phobic anorexia nervosa: a comparative study of 70 Chinese patients in Hong Kong. Psychol. Med. 23, 999–1017 (1993).

    Article  CAS  Google Scholar 

  3. Davis, C. et al. The role of physical activity in the development and maintenance of eating disorders. Psychol. Med. 24, 957–967 (1994).

    Article  CAS  Google Scholar 

  4. Feighner, J.P. et al. Diagnostic criteria for use in psychiatric research. Arch. Gen. Psychiatry 26, 57–63 (1971).

    Article  Google Scholar 

  5. Hotta, M. et al. The response of plasma adrenocorticotropin and cortisol to corticotropin-releasing hormone (CRH) and cerebrospinal fluid immunoreactive CRH in anorexia nervosa patients. J. Clin. Endocrinol. Metab. 62, 319–324 (1986).

    Article  CAS  Google Scholar 

  6. Liu, J.-P. et al. Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophyseal-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. J. Clin. Invest. 93, 1439–1450 (1994).

    Article  CAS  Google Scholar 

  7. Dunn, A.J. & Berridge, C.W. Physiological and behavioral responses to corticotropin-releasing factor administration: Is CRF a mediator of anxiety or stress responses? Brain Res. Rev. 15, 71–100 (1990).

    Article  CAS  Google Scholar 

  8. Burden, V.R. et al. Activity of the hypothalamopituitary-adrenal axis is elevated in rats with activity-based anorexia. J. Nutr. 123, 1217–1225 (1993).

    Article  CAS  Google Scholar 

  9. Piazza, P.V. et al. Corticosterone in the range of stress-induced levels possesses reinforcingproperties: Implications for sensation-seeking behaviors. Proc. Natl. Acad. Sci. USA 90, 11738–11742 (1993).

    Article  CAS  Google Scholar 

  10. Gull, W.W. Anorexia nervosa (apepsia hysterica, anorexia hysterica). Trans. Clin. Soc. London 7, 22–28 (1874).

    Google Scholar 

  11. Cecateili, S. et al. Expression of c-fos immunoreactivity in transmitter-characterized neurons after stress. Proc. Natl. Acad. Sci. USA 86, 9569–9573 (1989).

    Article  Google Scholar 

  12. Gratton, A. & Wise, R.A. Drug-and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. J. Neurosci. 14, 4130–4146 (1994).

    Article  CAS  Google Scholar 

  13. Novin, D. et al. In the activity stress paradigm (ASP) there are close relations between vital signs which allows us to predict longevity in rats with unfailing accuracy. Obesity Res. 3 (suppl. 3), 3735 (Abstr.)(1995).

    Google Scholar 

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Bergh, C., Södersten, P. Anorexia nervosa, self–starvation and the reward of stress. Nat Med 2, 21–22 (1996). https://doi.org/10.1038/nm0196-21

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