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The gene as the drug

Caplen et al. (pages 39–46) demonstrate that it is feasible to use liposomes to transfer a human gene in vivo. Can this vector mimic the ability of viruses to effectively transfer genetic information into target cells?

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  1. Caplen, N.J. et al. Nature Med. 1, 39–46 (1995).

    CAS  Article  Google Scholar 

  2. Rommens, J.M. et al. Science 245, 1059–1065 (1989).

    CAS  Article  Google Scholar 

  3. Riordan, J.R. et al. Science 245, 1066–1073 (1989).

    CAS  Article  Google Scholar 

  4. Kerem, B.–S. et al. Science 245, 1073–1080 (1989).

    CAS  Article  Google Scholar 

  5. Welsh, M.J. & Smith, A.E. Cell 73, 1251–1254 (1993).

    CAS  Article  Google Scholar 

  6. Rosenfeld, M.A. et al. Cell 68, 143–155 (1992).

    CAS  Article  Google Scholar 

  7. Crystal, R.G., Principal Investigator. Federal Register 58, 21737–21738 (1992).

    Google Scholar 

  8. Crystal, R.G. Personal communication, Recombinant DNA Advisory Committee. November 29, 1994.

    Google Scholar 

  9. Zabner, J. et al. Cell 75, 207–216 (1993).

    CAS  Article  Google Scholar 

  10. Crystal, R.G. et al. Nature Genet. 8, 42–51 (1994).

    CAS  Article  Google Scholar 

  11. Mastrangeli, A. et al. J clin Invest. 91, 225–234 (1993).

    CAS  Article  Google Scholar 

  12. Rosenfeld, M.A. et al. Human Gene Therapy 5, 331–342 (1994).

    CAS  Article  Google Scholar 

  13. Grubb, B.R. et al. Nature 371, 802–806 (1994).

    CAS  Article  Google Scholar 

  14. Yang, Y. et al. Proc natn Acad Scl U SA. 91, 4407–4411 (1994).

    CAS  Article  Google Scholar 

  15. Feigner, P.L. Liposome Res. 3, 3–16 (1993).

    Article  Google Scholar 

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Crystal, R. The gene as the drug. Nat Med 1, 15–17 (1995).

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