Loss of kidney filter function during nephrotic syndrome results in loss of protein from the blood into the urine (proteinuria). A new study mechanistically links proteinuria to dysregulated expression and post-transcriptional modification of the secreted glycoprotein angiopoietin-like-4 in kidney glomerular podocytes (pages 117–122).
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Affiliations
Jochen Reiser is in the Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
- Jochen Reiser
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Competing interests
J.R. is an inventor on issued and pending patents related to the discoveries of β3 integrin function and cathepsin L in podocytes and glomerular diseases. He stands to gain royalties from future commercialization.
Corresponding author
Correspondence to Jochen Reiser.
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