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Filtering new facts about kidney disease

Nature Medicine volume 17, pages 44–45 (2011)Cite this article

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Loss of kidney filter function during nephrotic syndrome results in loss of protein from the blood into the urine (proteinuria). A new study mechanistically links proteinuria to dysregulated expression and post-transcriptional modification of the secreted glycoprotein angiopoietin-like-4 in kidney glomerular podocytes (pages 117–122).

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Figure 1: Schematic outlining the development of reversible MCD in contrast to alternative pathways that cause progressive podocyte disease, such as focal segmental glomerulosclerosis (FSGS).

Katie Vicari

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Authors and Affiliations

  1. Jochen Reiser is in the Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA,

    Jochen Reiser

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  1. Jochen Reiser
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Correspondence to Jochen Reiser.

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Competing interests

J.R. is an inventor on issued and pending patents related to the discoveries of β3 integrin function and cathepsin L in podocytes and glomerular diseases. He stands to gain royalties from future commercialization.

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Reiser, J. Filtering new facts about kidney disease. Nat Med 17, 44–45 (2011). https://doi.org/10.1038/nm0111-44

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