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Histamine restricts cancer: nothing to sneeze at

Histamine produced by immature myeloid cells restricts the expression of inflammatory mediators and regulates leukocyte recruitment to sites of tissue stress. Unexpectedly, cancer susceptibility is increased in mice lacking histamine, thus revealing a previously unknown mechanism whereby immature myeloid cells contribute to cancer development (pages 87–95).

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Figure 1: Proposed role for histidine decarboxylase production by immature myeloid cells in inflammation-associated carcinogenesis.

Nesrine Affara and Katie Vicari


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Correspondence to Lisa M Coussens.

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Ruffell, B., Coussens, L. Histamine restricts cancer: nothing to sneeze at. Nat Med 17, 43–44 (2011).

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