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Histamine restricts cancer: nothing to sneeze at

Nature Medicine volume 17, pages 4344 (2011) | Download Citation

Histamine produced by immature myeloid cells restricts the expression of inflammatory mediators and regulates leukocyte recruitment to sites of tissue stress. Unexpectedly, cancer susceptibility is increased in mice lacking histamine, thus revealing a previously unknown mechanism whereby immature myeloid cells contribute to cancer development (pages 87–95).

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Author information

Affiliations

  1. Brian Ruffell and Lisa M. Coussens are in the Department of Pathology and Lisa M. Coussens is at the Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, California, USA.

    • Brian Ruffell
    •  & Lisa M Coussens

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Lisa M Coussens.

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DOI

https://doi.org/10.1038/nm0111-43

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