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Histamine restricts cancer: nothing to sneeze at

Nature Medicine volume 17, pages 43–44 (2011)Cite this article

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Histamine produced by immature myeloid cells restricts the expression of inflammatory mediators and regulates leukocyte recruitment to sites of tissue stress. Unexpectedly, cancer susceptibility is increased in mice lacking histamine, thus revealing a previously unknown mechanism whereby immature myeloid cells contribute to cancer development (pages 87–95).

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Figure 1: Proposed role for histidine decarboxylase production by immature myeloid cells in inflammation-associated carcinogenesis.

Nesrine Affara and Katie Vicari

References

  1. Dvorak, H.F. N. Engl. J. Med. 315, 1650–1659 (1986).

    Article  CAS  Google Scholar 

  2. Qian, B.Z. & Pollard, J.W. Cell 141, 39–51 (2010).

    Article  CAS  Google Scholar 

  3. Gabrilovich, D.I. & Nagaraj, S. Nat. Rev. Immunol. 9, 162–174 (2009).

    Article  CAS  Google Scholar 

  4. Medina, V.A. & Rivera, E.S. Br. J. Pharmacol. 161, 755–767 (2010).

    Article  CAS  Google Scholar 

  5. Bolton, E., King, J. & Morris, D.L. Semin. Cancer Biol. 10, 3–10 (2000).

    Article  CAS  Google Scholar 

  6. Yang, X.D. et al. Nat. Med. 17, 87–95 (2011).

    Article  CAS  Google Scholar 

  7. Ghosh, A.K., Hirasawa, N., Ohtsu, H., Watanabe, T. & Ohuchi, K. J. Exp. Med. 195, 973–982 (2002).

    Article  CAS  Google Scholar 

  8. Ohtsu, H. & Watanabe, T. Biochem. Biophys. Res. Commun. 305, 443–447 (2003).

    Article  CAS  Google Scholar 

  9. Cheng, P. et al. J. Exp. Med. 205, 2235–2249 (2008).

    Article  CAS  Google Scholar 

  10. Grivennikov, S. et al. Cancer Cell 15, 103–113 (2009).

    Article  CAS  Google Scholar 

  11. Schneider, E. et al. J. Exp. Med. 202, 387–393 (2005).

    Article  CAS  Google Scholar 

  12. Brandes, L.J., Queen, G.M. & LaBella, F.S. J. Cell. Biochem. 85, 820–824 (2002).

    Article  CAS  Google Scholar 

Download references

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  1. Brian Ruffell and Lisa M. Coussens are in the Department of Pathology and Lisa M. Coussens is at the Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, California, USA.,

    Brian Ruffell & Lisa M Coussens

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  1. Brian Ruffell
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  2. Lisa M Coussens
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Correspondence to Lisa M Coussens.

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Ruffell, B., Coussens, L. Histamine restricts cancer: nothing to sneeze at. Nat Med 17, 43–44 (2011). https://doi.org/10.1038/nm0111-43

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