News & Views | Published:

Catapulting clopidogrel pharmacogenomics forward

Nature Medicine volume 17, pages 4041 (2011) | Download Citation

The antiplatelet drug clopidogrel helps prevent stent-associated thrombosis, but the antiplatelet effects are quite variable and the clinical consequences can be serious. New findings show that the variability in clopidogrel efficacy is affected by the enzyme paraoxonase-1 (PON1), which is required for clopidogrel bioactivation (pages 110–116).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Textbook of Interventional Cardiology. 5th edn. Ch. 66, 1221–1240 (Elsevier, Philadelphia, 2008).

  2. 2.

    Plavix rival gains from studies. Wall Street Journal (30 August 2010).

  3. 3.

    et al. J. Am. Coll. Cardiol. 45, 246–251 (2005).

  4. 4.

    et al. N. Engl. J. Med. 356, 1020–1029 (2007).

  5. 5.

    et al. Nat. Med. 17, 110–116 (2011).

  6. 6.

    et al. Blood 108, 2244–2247 (2006).

  7. 7.

    et al. N. Engl. J. Med. 360, 363–375 (2009).

  8. 8.

    et al. Lancet 373, 309–317 (2009).

  9. 9.

    et al. N. Engl. J. Med. 360, 354–362 (2009).

  10. 10.

    et al. J. Am. Coll. Cardiol. 56, 134–143 (2010).

  11. 11.

    et al. J. Am. Med. Assoc. 304, 1821–1830 (2010).

  12. 12.

    et al. J. Am. Med. Assoc. 302, 849–857 (2009).

  13. 13.

    & J. Am. Coll. Cardiol. 56, 109–111 (2010).

Download references

Author information

Affiliations

  1. Eric J. Topol and Nicholas J. Schork are at the Scripps Translational Science Institute, the Scripps Research Institute, Scripps Genomic Medicine and Scripps Health, La Jolla, California, USA.

    • Eric J Topol
    •  & Nicholas J Schork
  2. Eric J. Topol is also at the Scripps Clinic, La Jolla, California, USA.

    • Eric J Topol

Authors

  1. Search for Eric J Topol in:

  2. Search for Nicholas J Schork in:

Competing interests

E.J.T. is a consultant/advisor to Sanofi-Aventis, Daiichi and Quest Diagnostics.

Corresponding author

Correspondence to Eric J Topol.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm0111-40

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing