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Adiponectin sphings into action

The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell survival. A new study now shows that these beneficial effects of adiponectin are dependent on sphingolipid metabolism (pages 55–63).

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Figure 1: Adiponectin increases cellular ceramidase activity in an AdipoR1- and AdipoR2-dependent manner, resulting in an increase in cellular S1P abundance and decrease in cellular ceramide abundance.

Katie Vicari

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Correspondence to Mark A Febbraio.

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Lancaster, G., Febbraio, M. Adiponectin sphings into action. Nat Med 17, 37–38 (2011). https://doi.org/10.1038/nm0111-37

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