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NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis

Nature Medicine volume 17, pages 31–32 (2011)Cite this article

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To the Editor:

Idiopathic pulmonary fibrosis (IPF) is a fatal disease, and there is a need for an improved understanding of its pathophysiology and for new therapeutic concepts. Recent work by Hecker et al.1 suggests that the generation of reactive oxygen species by the NADPH oxidase NOX-4 is involved in the pathophysiology of IPF. More specifically, the work suggests that NOX-4–dependent generation of reactive oxygen species is required for transforming growth factor-β1 (TGF-β1)-induced myofibroblast differentiation, extracellular matrix production and contractility. The authors provide the first elements to support the concept that NOX-4 might be a target for the treatment of pulmonary fibrosis.

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Figure 1: Thickness of lung arteries in idiopathic pulmonary fibrosis.

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Acknowledgements

We thank M. Kitaichi (National Hospital Organization, Kinki-chuo Chest Medical Center) and K.O. Leslie (Mayo Clinic) for helpful discussions. Mouse IgG2a antibody was a kind gift of G. Gabbiani (University of Geneva). This work was supported by grants from the Swiss National Foundation (to K.-H.K. and C.B.-A.) and the Swiss Pneumology Society and Société de Pneumologie de Langue Française (to S.C.).

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Authors and Affiliations

  1. Department of Pathology and Immunology, Medical School, University of Geneva, Geneva, Switzerland

    Jean-Claude Pache, Stephanie Carnesecchi, Christine Deffert, Yves Donati, Constance Barazzone-Argiroffo & Karl-Heinz Krause

  2. Department of Genetic and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland

    Jean-Claude Pache, Christine Deffert & Karl-Heinz Krause

  3. Department of Pediatrics, Medical School, University of Geneva, Geneva, Switzerland

    Stephanie Carnesecchi, Christine Deffert, Yves Donati & Constance Barazzone-Argiroffo

  4. Department of Rehabilitation and Geriatrics, Hospital of Trois Chêne, University Hospitals of Geneva, Geneva, Switzerland

    François R Herrmann

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  1. Jean-Claude Pache
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  2. Stephanie Carnesecchi
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Correspondence to Karl-Heinz Krause.

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Pache, JC., Carnesecchi, S., Deffert, C. et al. NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis. Nat Med 17, 31–32 (2011). https://doi.org/10.1038/nm0111-31

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