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  • Between Bedside and Bench
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Kidney complications: Factors that protect the diabetic vasculature

Nature Medicine volume 16, pages 40–41 (2010)Cite this article

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Bench to bedside

Diabetes can wreak havoc on the vasculature, leading to renal failure, blindness and cardiovascular disease. Such conditions are ultimately the result of reduced insulin production or insulin action, leading to increased concentrations of glucose and free fatty acids and abnormal concentration of lipoproteins in the blood. To identify targets for therapeutic intervention, most studies have focused on understanding how abnormal levels of such metabolites cause vascular pathology. Much less attention has been devoted to endogenous protective factors that may prevent or delay vascular complications.

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Figure 1: Diabetes causes activation or upregulation of several causal factors that promote vascular complications.

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Authors and Affiliations

  1. Christian Rask-Madsen and George L. King are at the Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.,

    Christian Rask-Madsen & George L King

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  1. Christian Rask-Madsen
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  2. George L King
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Correspondence to George L King.

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Rask-Madsen, C., King, G. Kidney complications: Factors that protect the diabetic vasculature. Nat Med 16, 40–41 (2010). https://doi.org/10.1038/nm0110-40

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