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A NOD for autophagy

Nature Medicine volume 16, pages 28–30 (2010)Cite this article

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Susceptibility to Crohn's disease has been linked to polymorphisms in genes involved in two pathophysiological pathways: autophagy and the recognition of bacterial peptidoglycan by nucleotide oligomerization domain-2 (NOD2), an intracellular receptor. Two studies link these pathways by showing that recognition of bacterial peptidoglycans by NOD2 induces autophagy and bacterial clearance.

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Figure 1: NOD2 activates the autophagy pathway.

Katie Vicari

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Authors and Affiliations

  1. Mihai G. Netea and Leo A.B. Joosten are in the Department of Medicine, Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands.,

    Mihai G Netea & Leo A B Joosten

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  1. Mihai G Netea
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  2. Leo A B Joosten
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Correspondence to Mihai G Netea.

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Netea, M., Joosten, L. A NOD for autophagy. Nat Med 16, 28–30 (2010). https://doi.org/10.1038/nm0110-28

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