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γ-secretase inhibitors: Notch so bad

γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with glucocorticoids could provide a more effective and safer approach (pages 50–58).

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Figure 1: Combined treatment of NOTCH-positive T-ALL with a γ-secretase inhibitor and dexamethasone.

Katie Ris-Vicari


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Grosveld, G. γ-secretase inhibitors: Notch so bad. Nat Med 15, 20–21 (2009).

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