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From lung injury to fibrosis

Two hallmarks of lung fibrosis are vascular leakage and recruitment of fibroblasts into the alveoli. Lysophosphatidic acid is now implicated as a major regulator of both parameters (pages 45–54).

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Figure 1: A look at lung fibrosis.

Katie Ris-Vicari

References

  1. Raghu, G., Weycker, D., Edelsberg, J., Bradford, W.Z. & Oster, G. Am. J. Respir. Crit. Care Med. 174, 810–816 (2006).

    Article  Google Scholar 

  2. Swigris, J.J., Kuschner, W.G., Kelsey, J.L. & Gould, M.K. Chest 127, 275–283 (2005).

    PubMed  Google Scholar 

  3. Tager, A.M. et al. Nat. Med. 14, 45–54 (2008).

    Article  CAS  Google Scholar 

  4. Pradere, J.P. et al. J. Am. Soc. Nephrol. 18, 3110–3118 (2007).

    Article  CAS  Google Scholar 

  5. Gardell, S.E., Dubin, A.E. & Chun, J. Trends Mol. Med. 12, 65–75 (2006).

    Article  CAS  Google Scholar 

  6. Zarbock, A., Singbartl, K. & Ley, K. J. Clin. Invest. 116, 3211–3219 (2006).

    Article  CAS  Google Scholar 

  7. Ware, L.B. & Matthay, M.A. N. Engl. J. Med. 342, 1334–1349 (2000).

    Article  CAS  Google Scholar 

  8. Willis, B.C. & Borok, Z. Am. J. Physiol. Lung Cell. Mol. Physiol. 293, L525–L534 (2007).

    Article  CAS  Google Scholar 

  9. Strieter, R.M., Gomperts, B.N. & Keane, M.P. J. Clin. Invest. 117, 549–556 (2007).

    Article  CAS  Google Scholar 

  10. Idell, S. Crit. Care Med. 31, S213–S220 (2003).

    Article  CAS  Google Scholar 

  11. Neidlinger, N.A., Larkin, S.K., Bhagat, A., Victorino, G.P. & Kuypers, F.A. J. Biol. Chem. 281, 775–781 (2006).

    Article  CAS  Google Scholar 

  12. Tager, A.M. et al. Am. J. Respir. Cell Mol. Biol. 31, 395–404 (2004).

    Article  CAS  Google Scholar 

  13. Keane, M.P. et al. J. Immunol. 159, 1437–1443 (1997).

    CAS  PubMed  Google Scholar 

  14. Meyer zu Heringdorf, D. & Jakobs, K.H. Biochim. Biophys. Acta 1768, 923–940 (2007).

    Article  CAS  Google Scholar 

  15. Reutershan, J. et al. J. Clin. Invest. 116, 695–702 (2006).

    Article  CAS  Google Scholar 

Download references

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K.L. has a research contract consulting with Dompé Pharma.

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Ley, K., Zarbock, A. From lung injury to fibrosis. Nat Med 14, 20–21 (2008). https://doi.org/10.1038/nm0108-20

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