Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Bad signals jam organelle traffic

Defects in organelle biogenesis and trafficking underlie a newly described genetic disorder. These defects are traced to the gene encoding a scaffolding protein that coordinates signal transduction events on late endosomes (pages 3845).

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: A constellation of recessive disorders of lysosome-related organelles and their impact on the specialized functions of selected cell types.

Katie Ris


  1. Bohn, G. et al. Nat. Med. 13, 36–43 (2006).

    Google Scholar 

  2. Wunderlich, W. et al. J. Cell Biol. 152, 765–776 (2001).

    CAS  Article  Google Scholar 

  3. Stinchcombe, J., Bossi, G. & Griffiths, G.M. Science 305, 55–59 (2004).

    CAS  Article  Google Scholar 

  4. Gunay-Aygun, M. et al. Semin. Thromb. Hemost. 30, 537–547 (2004).

    CAS  Article  Google Scholar 

  5. Ménasché, G. et al. J. Clin. Invest. 112, 450–456 (2003).

    Article  Google Scholar 

  6. Schiaffino, M.V. et al. Nat. Genet. 23, 108–112 (1999).

    CAS  Article  Google Scholar 

  7. Kurzbauer, R. et al. Proc. Natl. Acad. Sci. USA 101, 10984–10989 (2004).

    CAS  Article  Google Scholar 

  8. Lunin, V.V. et al. J. Biol. Chem. 279, 23422–23430 (2004).

    CAS  Article  Google Scholar 

  9. Teis, D., Wunderlich, W. & Huber, L.A. Dev. Cell 3, 803–814 (2002).

    CAS  Article  Google Scholar 

  10. Nazarian, R., Falcón-Pérez, J.M. & Dell'Angelica, E.C. Proc. Natl. Acad. Sci. USA 100, 8770–8775 (2003).

    CAS  Article  Google Scholar 

  11. Deacon, S.W., Nascimento, A., Serpinskaya, A.S. & Gelfand, V.I. Curr. Biol. 15, 459–463 (2005).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dell'Angelica, E. Bad signals jam organelle traffic. Nat Med 13, 31–32 (2007).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing