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Bad signals jam organelle traffic

Defects in organelle biogenesis and trafficking underlie a newly described genetic disorder. These defects are traced to the gene encoding a scaffolding protein that coordinates signal transduction events on late endosomes (pages 3845).

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Figure 1: A constellation of recessive disorders of lysosome-related organelles and their impact on the specialized functions of selected cell types.

Katie Ris

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Dell'Angelica, E. Bad signals jam organelle traffic. Nat Med 13, 31–32 (2007). https://doi.org/10.1038/nm0107-31

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