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A 'good death' for tumor immunology

A class of cell-killing chemotherapeutic agents seems to have an additional benefit. The drugs help prompt the immune system to turn against the tumor (pages 5461).

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Figure 1: Chemotherapy and immunogenicity: therapeutic strategies that promote CRT translocation to the tumor cell surface may give the immune system a boost by enhancing protective antitumor T-cell cross-priming.

Katie Ris


  1. Klebanoff, C.A., Gattinoni, L. & Restifo, N.P. Immunol. Rev. 211, 214–224 (2006).

    CAS  Article  Google Scholar 

  2. Obeid, M. et al. Nat. Med. 13, 52–59 (2006).

    Google Scholar 

  3. Ip, W.K. & Lau, Y.L. J. Immunol. 173, 189–196 (2004).

    CAS  Article  Google Scholar 

  4. Albert, M.L. et al. J. Exp. Med. 188, 1359–1368 (1998).

    CAS  Article  Google Scholar 

  5. Ackerman, A.L., Giodini, A. & Cresswell, P. Immunity 25, 607–617 (2006).

    CAS  Article  Google Scholar 

  6. Ostwald, J.T. & MacLennan, D.H. J. Biol. Chem. 249, 974–979 (1974).

    CAS  PubMed  Google Scholar 

  7. Johnson, S., Michalak, M., Opas, M. & Eggleton, P. Trends Cell Biol. 11, 122–129 (2001).

    CAS  Article  Google Scholar 

  8. Walters, J.J. & Berwin, B. Traffic 6, 1173–1182 (2005).

    CAS  Article  Google Scholar 

  9. Robert, J., Menoret, A. & Cohen, N. J. Immunol. 163, 4133–4139 (1999).

    CAS  PubMed  Google Scholar 

  10. Pike, S.E. et al. J. Exp. Med. 188, 2349–2356 (1998).

    CAS  Article  Google Scholar 

  11. Gold, L.I. et al. J. Investig. Dermatol. Symp. Proc. 11, 57–65 (2006).

    CAS  Article  Google Scholar 

  12. Fraser, S.A., Karimi, R., Michalak, M. & Hudig, D. J. Immunol. 164, 4150–4155 (2000).

    CAS  Article  Google Scholar 

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Storkus, W., Falo, L. A 'good death' for tumor immunology. Nat Med 13, 28–30 (2007).

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