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A 'good death' for tumor immunology

A class of cell-killing chemotherapeutic agents seems to have an additional benefit. The drugs help prompt the immune system to turn against the tumor (pages 5461).

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Figure 1: Chemotherapy and immunogenicity: therapeutic strategies that promote CRT translocation to the tumor cell surface may give the immune system a boost by enhancing protective antitumor T-cell cross-priming.

Katie Ris

References

  1. Klebanoff, C.A., Gattinoni, L. & Restifo, N.P. Immunol. Rev. 211, 214–224 (2006).

    Article  CAS  Google Scholar 

  2. Obeid, M. et al. Nat. Med. 13, 52–59 (2006).

    Google Scholar 

  3. Ip, W.K. & Lau, Y.L. J. Immunol. 173, 189–196 (2004).

    Article  CAS  Google Scholar 

  4. Albert, M.L. et al. J. Exp. Med. 188, 1359–1368 (1998).

    Article  CAS  Google Scholar 

  5. Ackerman, A.L., Giodini, A. & Cresswell, P. Immunity 25, 607–617 (2006).

    Article  CAS  Google Scholar 

  6. Ostwald, J.T. & MacLennan, D.H. J. Biol. Chem. 249, 974–979 (1974).

    CAS  PubMed  Google Scholar 

  7. Johnson, S., Michalak, M., Opas, M. & Eggleton, P. Trends Cell Biol. 11, 122–129 (2001).

    Article  CAS  Google Scholar 

  8. Walters, J.J. & Berwin, B. Traffic 6, 1173–1182 (2005).

    Article  CAS  Google Scholar 

  9. Robert, J., Menoret, A. & Cohen, N. J. Immunol. 163, 4133–4139 (1999).

    CAS  PubMed  Google Scholar 

  10. Pike, S.E. et al. J. Exp. Med. 188, 2349–2356 (1998).

    Article  CAS  Google Scholar 

  11. Gold, L.I. et al. J. Investig. Dermatol. Symp. Proc. 11, 57–65 (2006).

    Article  CAS  Google Scholar 

  12. Fraser, S.A., Karimi, R., Michalak, M. & Hudig, D. J. Immunol. 164, 4150–4155 (2000).

    Article  CAS  Google Scholar 

Download references

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Storkus, W., Falo, L. A 'good death' for tumor immunology. Nat Med 13, 28–30 (2007). https://doi.org/10.1038/nm0107-28

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