Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

News Feature: Hormone in the hot seat

Three years after scientists declared estrogen harmful to the heart, some say the hormone was unfairly maligned. Apoorva Mandavilli finds out why it's time to reopen the debate.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Writing Group for the Women's Health Initiative Investigators. JAMA 288, 321–333 (2002).

  2. Stampfer, M. & Colditz, G. Prev. Med. 20, 47–63 (1991).

    CAS  Article  Google Scholar 

  3. Hulley, S., et al. JAMA 280, 605–613 (1998).

    CAS  Article  Google Scholar 

  4. Clarkson, T.B. & Appt, S.E. Maturitas 51, 64–74 (2005).

    CAS  Article  Google Scholar 

  5. The Women's Health Initiative Steering Committee JAMA 291, 1701–1712 (2004).

  6. Harman, S.M. Climacteric 1, 3–12 (2005).

    Article  Google Scholar 

  7. American College of Obstetricians and Gynecologists Women's Health Care Physicians Obstet. Gynecol. 104 (Suppl.) (2004).

Download references

Author information

Author notes

  1. Apoorva Mandavilli is Nature Medicine's senior news editor.

    • Apoorva Mandavilli

Related links

Related links

Related links in Nature Research

A winning combination

Long-term hormone replacement linked to breast cancer

Reexamining estrogen

Related external links

Women's Health Initiative

KEEPS study

Early Versus Late Intervention Trial

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mandavilli, A. News Feature: Hormone in the hot seat. Nat Med 12, 8–9 (2006).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing