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Improving metabolism by increasing energy expenditure

Nature Medicine volume 12, pages 44–45 (2006)Cite this article

A reduction in mitochondrial activity and the subsequent decrease in energy expenditure contribute substantially to metabolic dysfunction in aging, insulin resistance and diabetes. Enhancing mitochondrial activity could improve metabolic homeostasis.

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Figure 1: Schematic representation of the main pathways involved in the control of energy expenditure.

Simon Fenwick

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Authors and Affiliations

  1. Institut de Génétique et Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP) and at the Institut Clinique de la Souris, Illkirch, 67404, France

    Johan Auwerx

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  1. Johan Auwerx
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Auwerx, J. Improving metabolism by increasing energy expenditure. Nat Med 12, 44–45 (2006). https://doi.org/10.1038/nm0106-44

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