Primary alterations in insulin signaling pathways are not the only way to reduce the body's sensitivity to insulin. By promoting the release of cytokines, liver inflammation can also lead to insulin resistance.
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Lazar, M. The humoral side of insulin resistance. Nat Med 12, 43–44 (2006). https://doi.org/10.1038/nm0106-43
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DOI: https://doi.org/10.1038/nm0106-43
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