Comparing gene expression patterns of pancreatic islets from normal and diabetic people show that the transcription factor ARNT/HIF1β is the most markedly reduced in humans with the disease. ARNT regulates many beta-cell genes, insulin secretion and glucose tolerance.
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Czech, M. ARNT misbehavin' in diabetic beta cells. Nat Med 12, 39–40 (2006). https://doi.org/10.1038/nm0106-39
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DOI: https://doi.org/10.1038/nm0106-39
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