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One enzyme inactivates two antibiotics

A single enzyme is responsible for antibiotic resistance to two very different drugs (pages 83–88).

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Figure 1: Intermediate and low levels of resistance can serve as stepping-stones for the evolution of bacteria with inherited resistance to clinical concentrations of antibiotics.


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Klugman, K., Levin, B. One enzyme inactivates two antibiotics. Nat Med 12, 19–20 (2006).

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