For decades cancer biologists have thought of oncogenes in terms of their ability to prompt tumor growth and survival, acting within the cancer cell. That viewpoint is now changing to take into account data showing that oncogenes influence inflammation. Insights now emerge from work on Ras and the proinflammatory mediator interleukin-8, produced by tumor-infiltrating immune cells.
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References
Coussens, L.M. & Werb, Z. Nature 420, 860–867 (2002).
Balkwill, F. & Mantovani, A. Lancet 357, 539–545 (2001).
Reedy, J. Clio Medica 10, 227–238 (1975).
Dvorak, H.F. N. Engl. J. Med. 315, 1650–1659 (1986).
Sparmann, A. & Bar-Sagi, D. Cancer Cell 6, 447–458 (2004).
Karin, M. J. Biol. Chem. 270, 16483–16486 (1995).
Matsusaka, T. et al. Proc. Natl. Acad. Sci. USA 90, 10193–10197 (1993).
Yasumoto, K. et al., J. Biol. Chem. 267, 22506–22511 (1992).
Matsushima, K. et al., J. Exp. Med. 167, 1883–1893 (1988).
Becker, C. et al. Immunity 21, 491–501 (2004).
Greten, F.R. et al. Cell 118 285–296 (2004).
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Karin, M. Inflammation and cancer: the long reach of Ras. Nat Med 11, 20–21 (2005). https://doi.org/10.1038/nm0105-20
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DOI: https://doi.org/10.1038/nm0105-20
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