Three studies show that cells are protected against intracellular pathogens by autophagy, a process that degrades cytoplasmic components in bulk. The work may have implications for the development of vaccines against pathogens such as Mycobacterium tuberculosis, Streptococcus pyogenes and Shigella flexneri.
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References
Dunn, W.A. Jr. Trends Cell Biol. 4, 139–143 (1994).
Dunn, W.A. Jr. J. Cell Biol. 110, 1923–1933 (1990).
Dunn, W.A. Jr. J. Cell Biol. 110, 1935–1945 (1990).
Walker, D.H., Popov, V.L., Crocquet-Valdes, P.A., Welsch, C.J. & Feng, H.M. Lab. Invest. 76, 129–138 (1997).
Pizarro-Cerda, J., Moreno, E., Sanguedolce, V., Mege, J.L. & Gorvel, J.P. Infect. Immun. 66, 2387–2392 (1998).
Sturgill-Koszycki, S. & Swansson, M.S. J. Exp. Med. 192, 1261–1272 (2000).
Dorn, B.R., Dunn, W.A. & Progulske-Fox, A. Infect. Immun. 69, 5698–5708 (2001).
Rich, K.A., Burkett, C. & Webster P. Cell. Microbiol. 5, 455–468 (2003).
Kirkegaard, K., Taylor, M.P. & Jackson, W.T. Nat. Rev. Microbiol. 2, 301–314 (2004).
Nakagawa, I. et al. Science 306, 1037–1040 (2004).
Gutierrez, M.G. et al. Cell 199, 753–766 (2004).
Russell, D.G. Nat. Rev. Mol. Cell Biol. 2, 569–577 (2001).
Thilo, L. & de Chastellier, C. in J. P. Gorvel (ed.) Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis 153–169. (Kluwer Academic/Plenum Publishers, New York, 2004).
MacMicking, J.D., Taylor, G.A. & McKinney, J.D. Science 302, 654–659 (2003).
Ogawa, M. et al. Science published online 2 Dec 2004 (doi: 10.1126/science.1106036).
Sansonetti, P.J. Nat. Rev. Immunol. 4, 953–964 (2004).
Hernandez, L.D., Pypaert, M., Flavell, R.A. & Galán, J.E. J. Cell Biol. 163, 1123–1131 (2003).
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Gorvel, JP., de Chastellier, C. Bacteria spurned by self-absorbed cells. Nat Med 11, 18–19 (2005). https://doi.org/10.1038/nm0105-18
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DOI: https://doi.org/10.1038/nm0105-18
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