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The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies

A new theory about the development of autoimmunity has emerged from a surprising and disparate set of observations. The elements include antibodies that recognize antibodies, and a peculiar structural relationship between a sense- and antisense-encoded protein (pages 72–79).

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Figure 1: Chain of antibodies.
Figure 2: Antisense peptides and the idiotypic network.


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Shoenfeld, Y. The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies. Nat Med 10, 17–18 (2004).

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