Post-menopausal women are treated with estrogen-receptor binding compounds during hormone replacement therapy. But new imaging studies in mice hint that the estrogen receptor may be responding primarily to estrogen-independent stimuli in some tissues (pages 82–86).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zandi, P.P. et al. Hormone replacement therapy and incidence of Alzheimer disease in older women: The cache county study. JAMA 288, 2123–2129 (2002).
Nelson, H.D., Humphrey, L.L., Nygren, P., Teutsch, S.M. & Allan, J.D. Postmenopausal hormone replacement therapy: Scientific review. JAMA 288, 872–881 (2002).
Rossouw, J.E. et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results. From the Women's Health Initiative randomized controlled trial. JAMA 288, 321–333 (2002).
Ciana, P. et al. In vivo imaging of transcriptionally active estrogen receptors. Nature Med. 9, 82–86 (2003).
Tremblay, G.B. & Giguere, V. Coregulators of estrogen receptor action. Crit. Rev. Eukaryot. Gene Expr. 12, 1–22 (2002).
Hewitt, S.C. & Korach, K.S. Estrogen receptors: Structure, mechanisms and function. Rev. Endocr. Metab. Disord. 3, 193–200 (2002).
Lee, A.V., Cui, X. & Oesterreich, S. Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer. Clin. Cancer Res. 7, 4429s–4435s.
Escriva, H., Delaunay, F. & Laudet, V. Ligand binding and nuclear receptor evolution. Bioessays 22, 717–727 (2000).
Giguere, V. To ERR in the estrogen pathway. Trends Endocrinol. Metab. 13, 220–225 (2002).
Ciana, P. et al. Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol. Endocrinol. 15, 1104–1113 (2001).
Levin, E.R. Cellular functions of plasma membrane estrogen receptors. Steroids 67, 471–475 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Greene, G. In vivo imaging reveals estrogen receptor's hidden personality. Nat Med 9, 22–23 (2003). https://doi.org/10.1038/nm0103-22
Issue Date:
DOI: https://doi.org/10.1038/nm0103-22