SADS, a new component of the Fas-mediated apoptotic pathway, is downregulated in patients with colon carcinoma. Could this dowregulation be a widespread mechanism of tumor cell immune evasion? (pages 88–93)
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Bob Crimi
References
Thompson, C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456–1462 (1995).
Berke, G. The CTL's kiss of death. Cell 81, 9–12 (1995).
Shiraki, K., Tsuji, N., Shioda, T., Isselbacher, K.J. & Takahashi, H. Expression of Fas ligand in liver metastases on human colonic adenocarcinomas. Proc. Natl. Acad. Sci. USA 94, 6420–6425 (1997).
Suzuki, A. et al. SADS: A new component of Fas-DISC is the accelerator for cell death signaling and is down-regulated in patients with colon carcinoma. Nature Med. 7, 88–93 (2000).
Martin, S.J. & Green, D.R. Protease activation during apoptosis. Death by a thousand cut? Cell 82, 349–352 (1995).
Scaffidi, C. et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675–1687 (1998).
Imai, Y. et al. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase 8 during apoptosis. Nature 398, 777–785 (1999).
Li, H., Zhu, H., Xu, C. & Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491–501 (1998).
Enari, M. et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43–50 (2000).
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Takahashi, H. A SADS defect in tumor cells provides optimism. Nat Med 7, 26–27 (2001). https://doi.org/10.1038/83306
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DOI: https://doi.org/10.1038/83306
