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Is tissue plasminogen activator a threat to neurons?

Nature Medicine volume 7, pages 17–18 (2001)Cite this article

The clot-busting drug tissue plasminogen activator (tPA) is currently the only FDA-approved therapy for acute stroke. However, increasing evidence suggests that tPA can also contribute to excitotoxic neuronal damage in animal models of stroke. (pages 59–64)

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Figure 1: The NMDA receptor is probably composed of four subunits (inset), one of which, NR1, is illustrated here.

Bob Crimi

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Authors and Affiliations

  1. Department of Pharmacology Emory University, Atlanta, Georgia, USA

    Stephen F. Traynelis

  2. Center for Neuroscience and Aging The Burnham Institute, La Jolla, California, USA

    Stuart A. Lipton

Authors
  1. Stephen F. Traynelis
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  2. Stuart A. Lipton
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Traynelis, S., Lipton, S. Is tissue plasminogen activator a threat to neurons?. Nat Med 7, 17–18 (2001). https://doi.org/10.1038/83289

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