Abstract
The glycosaminoglycan hyaluronic acid has been identified as a second placental receptor for Plasmodium falciparum-infected erythrocytes. Discovering the factors that allow this parasite to stick to the placenta during pregnancy may provide clues about how malaria infects other organs (86–90).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Beeson, J.G. et al. Adhesion of Plasmodium falciparum-infected erythrcoytes to hyaluronic acid in placental malaria. Nature Med. 6, 86–90 (2000).
Robert, C. et al. Chondroitin-4-sulphate (proteoglycan), a receptor for Plasmodium falciparum-infected erythrocyte adherence on brain microvascular endothalial cells. Res. Immunol. 146, 383– 393 (1995).
Rogerson, S.J., Chaiyaroi, S.C., Ng, K., Reeder, J.C. & Brown, G.V. Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. J. Exp. Med. 182, 15–20 (1995).
Fried, M & Duffy, P. Adherence of Plasmodium falciparum to Chondroitin sulfate A in the human placenta. Science, 272, 1502–1504 (1996).
Laurent, T.C. & Fraser, J.R.E. Hyaluronan. FASEB J., 6, 2397–2404 ( 1992).
Beeson, J. G., Chai, W., Rogerson, S.J., Lawson, A.M. & Brown, G.V. Inhibition of binding of malaria-infected erythrocytes by a tetradecasaccharide fraction from chondroitin sulfate A. Infect. Immun. 66, 3397–3402 (1998).
Fried, M., Nosten, F., Brockman, A., Brabin, B.J. & Duffy, P.E. Maternal antibodies block malaria. Nature 395, 851–852 ( 1998).
Reeder, J.C. et al. The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein-1, Proc. Natl. Acad. Sci. USA, 96, 5198–5202 (1999)
Buffet, P.A. et al. Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection. Proc. Natl. Acad. Sci, USA 96, 12743– 12748 (1999).
Chen, Q. et al. Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum . J. Exp. Med. 187, 15– 23 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wahlgren, M., Spillmann, D. Sticky sugars attract malaria to the fetus. Nat Med 6, 25–26 (2000). https://doi.org/10.1038/71490
Issue Date:
DOI: https://doi.org/10.1038/71490