Sticky sugars attract malaria to the fetus

Abstract

The glycosaminoglycan hyaluronic acid has been identified as a second placental receptor for Plasmodium falciparum-infected erythrocytes. Discovering the factors that allow this parasite to stick to the placenta during pregnancy may provide clues about how malaria infects other organs (86–90).

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Hyaluronic acid, chondroitin sulfate A, and other unknown receptors are present on the syncytiotrophoblasts that line the placenta.

References

  1. 1

    Beeson, J.G. et al. Adhesion of Plasmodium falciparum-infected erythrcoytes to hyaluronic acid in placental malaria. Nature Med. 6, 86–90 (2000).

  2. 2

    Robert, C. et al. Chondroitin-4-sulphate (proteoglycan), a receptor for Plasmodium falciparum-infected erythrocyte adherence on brain microvascular endothalial cells. Res. Immunol. 146, 383– 393 (1995).

  3. 3

    Rogerson, S.J., Chaiyaroi, S.C., Ng, K., Reeder, J.C. & Brown, G.V. Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. J. Exp. Med. 182, 15–20 (1995).

  4. 4

    Fried, M & Duffy, P. Adherence of Plasmodium falciparum to Chondroitin sulfate A in the human placenta. Science, 272, 1502–1504 (1996).

  5. 5

    Laurent, T.C. & Fraser, J.R.E. Hyaluronan. FASEB J., 6, 2397–2404 ( 1992).

  6. 6

    Beeson, J. G., Chai, W., Rogerson, S.J., Lawson, A.M. & Brown, G.V. Inhibition of binding of malaria-infected erythrocytes by a tetradecasaccharide fraction from chondroitin sulfate A. Infect. Immun. 66, 3397–3402 (1998).

  7. 7

    Fried, M., Nosten, F., Brockman, A., Brabin, B.J. & Duffy, P.E. Maternal antibodies block malaria. Nature 395, 851–852 ( 1998).

  8. 8

    Reeder, J.C. et al. The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein-1, Proc. Natl. Acad. Sci. USA, 96, 5198–5202 (1999)

  9. 9

    Buffet, P.A. et al. Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection. Proc. Natl. Acad. Sci, USA 96, 12743– 12748 (1999).

  10. 10

    Chen, Q. et al. Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum . J. Exp. Med. 187, 15– 23 (1998).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wahlgren, M., Spillmann, D. Sticky sugars attract malaria to the fetus. Nat Med 6, 25–26 (2000). https://doi.org/10.1038/71490

Download citation