Seeing what Alzheimer saw—with magnetic resonance microscopy

Abstract

The search for methods to detect in vivo the histopathology of Alzheimer disease moves a step closer with a recent demonstration that amyloid plaques in autopsy specimens can be visualized with magnetic resonance microscopy.

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Figure 1: T1-weighted volumetric magnetic resonance images (voxel-size 1.0 mm3) of the brain (upper left panel) and hippocampus (upper right panel), taken from a subject with Alzheimer disease, allow visualization of atrophy, but do not allow visualization of neuritic plaques.

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Fox, N., Rossor, M. Seeing what Alzheimer saw—with magnetic resonance microscopy. Nat Med 6, 20–21 (2000). https://doi.org/10.1038/71481

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