Abstract
The search for methods to detect in vivo the histopathology of Alzheimer disease moves a step closer with a recent demonstration that amyloid plaques in autopsy specimens can be visualized with magnetic resonance microscopy.
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References
Mirra, S.S. et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479– 486 (1991).
Black, S.E. The search for diagnostic and progression markers in AD — So near but still too far? Neurology 52, 1533– 1534 (1999).
Benveniste, H., Einstein, G., Kim, K.R., Hulette, C. & Johnson, G.A. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc. Natl. Acad. Sci. USA 96, 14079–14084 (1999).
Jack, C.R. et al. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology 49, 786– 794 (1997).
Fox, N.C., Warrington, E.K. & Rossor, M.N. Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease. Lancet 353, 2125 (1999).
Schenk, D. et al. Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPP mouse. Nature 400, 173–177 (1999).
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Fox, N., Rossor, M. Seeing what Alzheimer saw—with magnetic resonance microscopy. Nat Med 6, 20–21 (2000). https://doi.org/10.1038/71481
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DOI: https://doi.org/10.1038/71481