Winning the battle of graft versus host


During hematopoietic stem cell transplantation, donor cell subsets mediate the delicate balance between graft rejection and the development of graft-versus-host disease. Is it possible to manipulate donor cell populations to facilitate engraftment of highly enriched hematopoietic stem cells in allogeneic recipients?

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Figure 1: Mechanisms for prevention of marrow graft rejection.


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Martin, P. Winning the battle of graft versus host. Nat Med 6, 18–19 (2000).

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