Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Winning the battle of graft versus host

Nature Medicine volume 6, pages 18–19 (2000)Cite this article

Abstract

During hematopoietic stem cell transplantation, donor cell subsets mediate the delicate balance between graft rejection and the development of graft-versus-host disease. Is it possible to manipulate donor cell populations to facilitate engraftment of highly enriched hematopoietic stem cells in allogeneic recipients?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Mechanisms for prevention of marrow graft rejection.

References

  1. Gandy, K.L., Domen, J., Aguila, H. & Weissman, I.L. CD8+TCR+ and CD8+TCR− cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 11, 579–590 (1999).

    Article  CAS  Google Scholar 

  2. Martin, P.J. Prevention of allogeneic marrow graft rejection by donor T cells that do not recognize recipient alloantigens: potential role of a veto mechanism. Blood 88, 962–969 ( 1996).

    CAS  PubMed  Google Scholar 

  3. Martin, P.J., Akatsuka, Y., Hahne, M. & Sale, G. Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection. Blood 92, 2177– 2181 (1998).

    CAS  PubMed  Google Scholar 

  4. Martin, P.J. Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans. J. Exp. Med. 178, 703–712 ( 1993).

    Article  CAS  Google Scholar 

  5. Martin, P.J. et al. A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients. Blood 94, 2192– 2199 (1999).

    CAS  PubMed  Google Scholar 

  6. Kaufman, C.L. et al. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84, 2436–2446 ( 1994).

    CAS  PubMed  Google Scholar 

  7. Asiedu, C. et al. Immunoregulatory role of CD8α in the veto effect. Transplantation 67, 372–380 (1999).

    Article  CAS  Google Scholar 

  8. Cudkowicz, G. & Bennett, M. Peculiar immunobiology of bone marrow allografts. I. Graft rejection by irradiated responder mice. J. Exp. Med. 134, 83–102 ( 1971).

    Article  CAS  Google Scholar 

  9. Aversa, F. et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N. Engl. J. Med. 339, 1186–1193 (1998).

    Article  CAS  Google Scholar 

  10. Mackall, C.L., Hakim, F.T. & Gress, R.E. Restoration of T-cell homeostasis after T-cell depletion . Sem. Immunol. 9, 339– 346 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, D2-100, P.O. Box 19024, Seattle, 98109-1024, Washington, USA

    Paul J. Martin

Authors
  1. Paul J. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Martin, P. Winning the battle of graft versus host. Nat Med 6, 18–19 (2000). https://doi.org/10.1038/71472

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/71472

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing